Do Non-Steroidal Anti-Inflammatory Drugs Increase the Risk for Non- or Mal-Union Following Acute Fracture? A Literature Review

Author

Bryan Moritz, Augsburg University

Date of Award

2018

Document Type

Open Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)

Department

Physician Assistant Studies

First Advisor

Eric Barth

Abstract

NSAID medications are among the most commonly used analgesic medications world wide, and it was estimated in 2010 (updated 2015 data is expected to be published next year) that about 29 million adults in the United States regularly used NSAID medications at least three times per week for more than three months. Fracture healing has been shown to be dependent on the inflammatory cascade. NSAID medication use appears to have a mechanistic in-vivo and in-vitro animal risk for the development of non- and mal-union following fracture. However, human data is lacking to support total avoidance of this analgesic option for all patients.

Identifier

SC11.PAS.2018.Moritz.B

Recommended Citation

Moritz, Bryan, "Do Non-Steroidal Anti-Inflammatory Drugs Increase the Risk for Non- or Mal-Union Following Acute Fracture? A Literature Review" (2018). Theses and Graduate Projects. 364.
https://idun.augsburg.edu/etd/364