Date of Award

8-13-2024

Document Type

Open Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)

Department

Physician Assistant Studies

First Advisor

Vanessa Bester

Abstract

Background: This literature review evaluates the utilization of various types of stem cells in the treatment of osteoarthritis.

Purpose: To assess the different types of stem cell therapy available in an attempt to determine its effectiveness and viability as a long term therapy option.

Methods: Articles were found by searching Augsburg Library Services, Google Scholar, and PubMed for recent, original studies using both allogeneic or autologous stem cells from a variety of cell lines including bone marrow and adipose tissue.

Conclusions: The utilization of stem cells as a viable treatment option for osteoarthritis shows improvement in pain management and return of function. Most studies showed an improvement in Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores, but did not show improvement to cartilage or bone features, evaluated by Kellgren-Lawrence scale. Despite this, stem cell use could provide a more effective alternative to therapy and pain management as well as a less costly, less invasive treatment than knee replacement surgery. The utilization of autologous stem cells helps with the accessibility of the treatment, however allogeneic options should still be pursued for those who may not be able to provide autologous cells. Further studies will need to be done to fully assess the long term effectiveness and viability of stem cells as a treatment option for osteoarthritis of the knee.

Identifier

SC 11.PAS.2024.Krist.K

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