Date of Award

8-15-2020

Document Type

Open Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)

Department

Physician Assistant Studies

First Advisor

Vanessa Bester Ed.D, PA-C

Abstract

SARS-CoV-2, a novel coronavirus reached pandemic status by the World Health Organization in the spring of 2020. As a novel virus, analysis of the early literature on the clinical manifestations of SARS-CoV-2 is imperative to help guide clinical practice and inform future research. Early studies about the clinical manifestation of the virus showed a proportion of hospitalized patients developing renal abnormalities and AKI. This paper analyzed literature through searching the PubMed database to assess whether renal abnormalities and AKI were present in hospitalized SARS-CoV-2 patients, how the renal abnormalities manifested themselves in patients, and the associated treatment and prognosis of those patient who developed renal abnormalities.

It was found that presence of comorbidities, advancing age, and severity of illness all correlated with development of AKI. The literature showed the pooled incidence of AKI in hospitalized patients to be from 0-36.6% and the presence of hematuria, proteinuria, elevated BUN, and elevated serum creatinine was frequently reported. Continuous renal replacement therapy is the mainstay of treatment for AKI and there is no research published on treatments for AKI specific to SARS-CoV-2. Renal abnormalities and AKI were shown to be linked with a higher mortality rate and increased the risk of in-hospital death by 3.07 to 5.3-fold. These findings indicate the need for more research on how to monitor for early renal dysfunction and what the best timing and treatment interventions are to try to help mitigate the high risk of mortality associated with hospitalized SARS-CoV-2 patients with renal complications.

Identifier

SC 11.PAS.2020.Waaraniemi.M

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