Date of Award
Open Access Thesis
MS in Physician Assistant Studies (PA)
Physician Assistant Studies
Hemophilia describes a group of genetic disorders that lead to the dysfunction of proteins involved in the clotting cascade.1 These proteins, also known as coagulation factors, are required to form clots and ultimately cessate bleeding. Although there are three distinct forms of congenital hemophilia (hemophilia A, hemophilia B, and hemophilia C), the affected proteins (factor VIII, factor IX, and factor XI, respectively), are within the same pathway leading to the formation of a clot. In condensed terms, each of these factors play a role in the ultimate activation of thrombin, which activates fibrinogen to form a fibrin clot and solidify the platelet plug. In patients with hemophilia, the affected protein is absent or deficient, leading to prolonged bleeding times.
Johnson, Chelsea, "Physical Activity Guidelines in Patients with Hemophilia: Benefits, Barriers, and Recommendations" (2019). Theses and Graduate Projects. 946.