Date of Award
Open Access Thesis
MS in Physician Assistant Studies (PA)
Physician Assistant Studies
Hemophilia is a congenital X-linked bleeding disorder that results from a deficiency of one of two coagulation factors. The majority of individuals with hemophilia are deficient in factor VIII (FVIII), known as hemophilia A. I turned to the literature to learn more about the occurrence and treatment of inhibitors in severe hemophilia A. Reflecting on the history of hemophilia and the progression of hemophilia treatment, it is difficult to imagine that only sixty years ago, whole blood transfusion was the only treatment available, and the life expectancy of individuals with hemophilia was under twenty years. Despite numerous recent advancements, medicine has not yet been able to achieve hemostasis with the use of exogenous products in a completely safe and effective manner. Moving forward, further research involving the prevention of inhibitor development is essential.
Colling, Julia, "Historical and Current Management of Hemophilia: A Focus on Inhibitor Development and Treatment in Severe Hemophilia A" (2018). Theses and Graduate Projects. 324.