Date of Award


Document Type

Restricted Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)


Physician Assistant Studies

First Advisor

Meredith Wold


Depression is a prevalent consequence of stroke impacting one-third or more of patients in the years immediately following their stroke. Given its prevalence and its associations with poorer functional outcomes, decreased quality of life, and increased mortality, interventions to prevent poststroke depression are gaining attention. Evidence is mounting to support the efficacy of prophylactic antidepressants to reduce the incidence of depression after stroke. This paper will review the results of those studies and discuss the implications of their findings. Furthermore, it will discuss the safety and feasibility of this preventive strategy. Additionally, as the identification of risk factors for poststroke depression can facilitate a more targeted application of this intervention, the research analyzing those variables most highly associated with depression will be reviewed. Finally, recommendations for ongoing research and clinical applications will be discussed.