Date of Award


Document Type

Restricted Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)


Physician Assistant Studies

First Advisor

Eric Van Hecke, MPAS, PA-C, CAQ-EM


Background: Malaria remains a significant burden that affects millions of people in Sub-Saharan Africa and Southeast Asia. Artemisinin-based combination therapies (ACT) are widely used for the treatment of Plasmodium falciparum malaria in endemic areas. Exchange transfusion has been used since 1974 as an adjunct for treatment of malaria. But its use has been subject to controversies as its role has not been clearly demonstrated.

Purpose: To determine the best treatment for Plasmodium falciparum malaria.

Methods: A comprehensive literature review was conducted using google scholar, and PubMed using the search terms antimalarial drugs, exchange transfusion, ACT. Inclusion criteria were studies from 2015 to present and exclusion criteria were studies that were older than 2015.

Conclusions: ACTs remain the first line treatment for Plasmodium falciparum malaria. They are effective against Plasmodium falciparum and well tolerated by patients. The evidence for exchange transfusion efficacy remains limited. Exchange transfusion is no longer recommended for treatment of Plasmodium falciparum malaria.


SC 11.PAS.2022.Adjagodo.A