Date of Award

Summer 8-12-2021

Document Type

Open Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)


Physician Assistant Studies

First Advisor

Kristen Lindvall


Background: Esophageal malignancy and severe benign esophageal disorders are now treated by esophagectomy. Although mortality rates after esophagectomy have progressively decreased, many patients continue to suffer from increasing problems despite advances in patient selection, surgical techniques, and postoperative care. The purpose of this research is to determine the perioperative variables that affect morbidity and mortality after esophagectomy.

Methods: A thorough search of Google Scholar, UpToDate, and the Lindell Library was conducted to find previously published papers describing the different outcomes related to esophagectomy. This research consulted a total of 30 reviews and two publications. The esophagus’s architecture, perioperative evaluations, surgical methods, and anastomoses that reduce morbidity and mortality after esophagectomy were all investigated.

Discussion: Patient selection was risk stratified using ERAS criteria and the Charlson score. A recent study has shown that minimally invasive access is linked with better results than more intrusive approaches. According to further research, hospital duration of stay and surgery volume are related in an inverse manner. In the postoperative period, the ERAS protocol had a significant impact on postoperative care.

Conclusion: In recent decades, surgical and medical advances have improved the post-esophageal resection results, although overall morbidity and death rates remain high. Perioperative factors that influence postoperative outcomes have been discovered and are the subject of this review. Centralization of preoperative and postoperative care, less invasive esophagectomy techniques, and surgical care in high-volume facilities should enhance post-esophagectomy outcomes.


SC 11.PAS.2021.Jakupi.L