Date of Award


Document Type

Open Access Thesis

Degree Name

MS in Physician Assistant Studies (PA)


Physician Assistant Studies

First Advisor

Ryane Lester PA-C


Background: With the advent of newer and 􏰖safer􏰗 fluids there have been numerous trials and studies conducted to test the safety and validity of colloids. Are colloids more effective then crystalloid for emergent resuscitation? The purpose of this systematic literature review is to assess the claims on treatment success and explore safety to gain clarity on which fluid is the best treatment for the patient.

Methods: A systematic database search was conducted from 2006 to the present. The search utilized such sources as PubMed, UpToDate and ScienceDirect. This search included more than 70 journal articles, where 24 articles were selected for review for their credibility and usage within the medical community.

Results: Considering the reviewed articles, it seems that the benefits may not outweigh the risks inherent with colloids. In summary, using colloids as an alternative to crystalloids made little to no difference in the cause of mortality. However, there was evidence that colloids can increase the need for renal therapies overall.

Conclusion: Colloids were merely marginal, if at all, more effective than crystalloids in reducing the mortality rates, but with the added risk of renal dysfunction. There are instances where colloids might be selected, but those occurrences should be critically challenged. In the end, it appears to be left up to clinical judgement, provider experience, and accessibility on which fluid selection is optimal.


SC 11.PAS.2020.Johnson.J